[LPGT] Fwd: PARA DIVULGAR

[Secretaria do Departemento de Genética]

A pedido da Profa. Eucleia, estou repassando

Susie

----- Mensagem encaminhada -----
De: epbcontel em usp.br
Para: secgen em fmrp.usp.br
Enviadas: Quarta-feira, 14 de Novembro de 2012 8:21:26
Assunto: PARA DIVULGAR




Susie: por favor, divulgue para nossos recém-doutores. 




Obrigada, 

Eucleia 



Prezados ex-alunos 

A Profa. Dra. Isabel Miranda Santos, docente da área de Imunologia da FMRP, enviou-me essa comunicação para que fosse distribuída entre vocês. 

Boa sorte! O endereço dela é: 

Departamento de Bioquímica e Imunologia 
Faculdade de Medicina de Ribeirão Preto 
Universidade de São Paulo 
Prédio Central 
Avenida Bandeirantes 3900 
Ribeirão Preto 14049-900 

imsantos em fmrp.usp.br 
ikfmsantos em gmail.com 
16 3602 0192 
16 3603 3267 

Profa. Eucleia 



Bolsa de Pós-doutorado FAPESP para participar em projeto para definir as bases genéticas e semioquímicas de resistência de bovinos a carrapatos. Início imediato. 

Oportunidade para obter treinamento em ferramentas para estudos genômicos de associação a fenótipos diversos e seleção genômica para melhoramento animal. 

Requisitos: doutorado em Genética, Parasitologia, Imunologia, Biotecnologia ou áreas afins, experiência em pesquisa com bovinos e trabalho de tese de doutorado publicado em revista indexada com corpo editorial seletivo. 

Financiamento: FAPESP-RCUK 

Coordenadores: 
Isabel de Miranda Santos, Universidade de São Paulo, Ribeirão Preto, Brasil 
Stephen Bishop, Roslin Institute e University of Edinburgh, Reino Unido 
Michael Bishop, Rothamsted Research, Reino Unido 

Title: 
DEFINING THE GENETIC AND SEMIOCHEMICAL BASIS OF TICK RESISTANCE IN CATTLE 

Technical Summary: 
Ticks have major impacts on animals and humans, worldwide. As well as transmitting disease, ticks lead to weight loss, anaemia and secondary infections. Acaricides are used for tick control, but this is problematic due to acaricide-resistance and chemical residue issues. But animals differ substantially in tick load, and this is genetically controlled. We hypothesize that the primary means by which host cattle differ in tick resistance is via their semiochemicals profiles, i.e. attractant/repellent volatile chemicals on the skin surface. We will perform a genome-wide association study (GWAS) for tick resistance, characterize semiochemicals which differ between cattle with high and low tick infestations (resistant and susceptible animals), identify genes differentially expressed between resistant and susceptible animals, integrate the results to obtain insights into the genetic and biochemical basis of tick resistance, and devise control options. The GWAS will be performed on >1000 Girolando cattle in Brazil, which will have been intensively phenotyped for tick burden with detailed epidemiological data (to identify risk factors). GWAS will be performed using data from the high density bovine SNP chip, giving >750,000 genotypes per animal, and analysed with current state-of-the-art techniques. From skin rubbings from animals with extreme tick counts, semiochemical profiles will be characterised using high resolution chromatography (GC, HPLC) and spectroscopic analysis. Gene expression will be performed using RNAseq on skin biopsies from extreme animals, before and after infestation, and pathways co-expressed with resistance determined. Together these data will inform on true extent of genetic control, underlying mechanisms and indicate actual loci contributing to variation. Validated SNPs for resistance will be identified, as will potential semiochemicals to be used as repellents.